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Nanoelectrode Array Sees Signals From Inside a Network of Cells

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Researchers at Harvard University have developed a nanoelectrode array capable of imaging the electrical signals within the living cells. While other technologies have been able to measure these signals, this new complimentary metal oxide semiconductor nanoelectrode array (called a CNEA) can measure these signal across an entire network of cells.

“It’s similar to an imager combining the light signal from each detector in a pixel array to form a picture; the CNEA combines the electrical signals from within each cell to map the network level electrical activities of the entire cell culture,” explained Donhee Ham, a professor at Harvard involved in the research, in an e-mail interview with IEEE Spectrum.

This network-level intracellular recording capability can be used, for example, to examine the effect of pharmaceuticals on a network of heart muscle tissue, enabling tissue-based screening of drug candidates. It could also help better understand how cells communicate with each other across a network.